Systemic Lupus Erythematosus
Stem Cell Therapy for Lupus
Stem Cell Therapy for Lupus
Systemic Lupus Erythematosus (SLE) is an autoimmune condition that affects the major body organs resulting in a high mortality rate. The treatment options for SLE are very limited. Stem Cell Therapy can be the best available treatment option in new times due to its innovation and novelty.
What is Lupus?
Systemic Lupus Erythematosus is an autoimmune disease that occurs as a result of immune system attacks and infections. SLE is the most common cause of lupus which causes damage to organs and tissues, joints, skin, kidneys, brain, lungs, and vasculature of the body. Until now, there hasn’t been any absolute treatment for SLE.
What causes Lupus?
The most common causes of SLE are:
Age and hormones
Environmental factors
Genetics
What are the risk factors for SLE?
Factors that can increase the risk of SLE incidence are:
Ethnicity and race – more in the Caucasian population
Family history of SLE
Sex (women are more prone to developing SLE)
Age (between ages 15-44)
What are the Systemic Lupus Erythematosus symptoms?
The most common symptoms of SLE are:
Swelling of joints
Joint pain
Fatigue
Hair loss
Anaemia
Blood clotting
Raynaud phenomenon
Headaches
Joint swelling
Nose and cheek rashes (butterfly rash)
Digestive tract problems
THE TREATMENT JOURNEY
How is Lupus commonly treated?
The commonly used treatments for SLE are:
Antimalarial drugs
Steroid creams
Anti-inflammatory medications
Corticosteroids
Disease-modifying drugs
How can Stem Cell Therapy treat Lupus?
Stem Cell Therapy is the most promising and unique intervention for SLE conditions. This treatment is specifically for patients who have less response to the traditional treatments and interventions. Mesenchymal Stem Cells can help in improving the disease activity, hypocomplementemia, and proteinuria in patients with Systemic Lupus Erythematosus. MSCs find the inflammation and damaged cells in the body to target them and repair or replace these cells with healthier ones. Moreover, Stem Cells also have contributed to the expansion of the regulatory T-cells to suppress the activity of T-cells.
Exosomes and Autoimmune diseases:
According to the clinical literature, Exosomes combined with MSCs help in autoimmune diseases by regulating the inflammatory cytokines, microenvironment, and immune cells. These processes have a potent relation with both adaptive and innate immune cells. In these cells, macrophages, Treg cells, Th17, immunoregulatory miRNAs, and CD4+Th1 are the most crucial ones.
Exosomes-combined-MSCs help in the regulation of T-Cell subsets in cases of autoimmune diseases. Moreover, the MSCs-Exosomes also aid in reducing the levels and concentration of pro-inflammatory Th17 and TH1 cytokines as IL-17AF, IL-12p70, and IL-6. However, the same MSCs-Exosomes help in increasing the concentration of anti-inflammatory Treg.
Therefore, MSCs-Exosomes increase the concentration of Treg cells and the related products without changing the concentration index of the lymphocytes to maintain the immunoregulation in the body. Similar effects of these cells are seen in the cases of RA (rheumatoid arthritis) and GVHD (graft-versus-host disease). MSCs-Exosomes help improve the GVHD by suppressing the differentiation of populations of the naïve T-cells. Macrophages constitute a crucial and major portion of the innate immunity of the human body, which can be regulated through the administration of MSCs-Exosomes. According to the different microenvironments, Mo (naïve macrophages) can be polarized into anti-inflammatory (M2) or pro-inflammatory (M1) to play different roles in different conditions. Along with the autoimmune conditions, this combination therapy can also help facilitate metabolic hemostasis to attenuate obesity and adipose inflammation. Moreover, MSCs-Exosomes can also promote the M1-M2 macrophage conversion to reduce the pro-inflammatory factors or effects of the macrophage M1.
How is the treatment at The Renue Medical Centre different?
The Stem Cell Therapy (SCT) at The Renue Centre is a holistic approach to treating Systemic Lupus Erythematosus (SLE).
Your Renue Journey does not end after your last day of SCT. We follow up with you to assert your progress, since the treatment for Lupus with Stem Cells consists of four phases:
Pre-treatment: Clinical evaluation, lab test results, and other diagnostic procedures. You will take our Renue Epigenetic Test powered by TruDiagnostics that will assert your biological age and other important health markers. Your TruDiagnostics test is part of the Renue Difference. It provides your doctor with critical information about your health and your true age (biological vs. chronological).
After the epigenetic test and we have received all your medical records, your Patient Advisor will assist you in planning your travel to Puerto Vallarta.Treatment day: The treatment starts with taking a specific amount of blood through apheresis. After taking the Stem Cells, the rest of the blood is returned to the donor.
30, 60 & 90 days after the treatment: To check for flare-up frequency, improvements, and other symptoms
Six months after treatment: Lab tests, flare-up frequency, clinical evaluation, and disease prognosis
YOUR TREATMENT JOURNEY
Experience Renue in Puerto Vallarta
Arrival Day
Upon arrival in Puerto Vallarta, a Renue representative will meet you at the airport in one of our Mercedes vans to transport you to the hotel.
Our representative will quickly review your schedule for the coming days for your peace of mind. Renue makes it worry-free, so don't worry!
Evening
You travelled all this way, so would you like to check our list of recommended restaurants? We can make reservations for you to enjoy the great food and warm atmosphere of Puerto Vallarta.
Check out the Renue chauffeur for recommendations, reservations, leisure activities, and your transportation needs.
A better life starts now!
Day 1. Enjoy The Renue Difference.
Count on your Renue Advisor and staff to help you have a pleasant experience. Our Renue chauffeur will pick you up from the hotel and take you to The Renue Medical Centre in the Joya Hospital. Our staff will welcome and assist you at the Centre.
Our staff will check you in at the Centre and take you on a tour of the facilities, including The Renue Laboratory, where your stem cells and exosomes are produced. You will also visit the Hyperbaric Chamber facility, an essential part of The Renue Difference.
After your check-in, our medical associates will proceed with any necessary blood work or tests organized by your Patient Advisor.
After that, you will meet with your doctor to review your file. Then, your doctor will make any adjustments to your treatment schedule submitted by your Renue Patient Advisor.
Once your doctor has reviewed your file, additional testing might be required—for example, X-Rays, MRIs, and others.
After that, you will have your first Hyperbaric Oxygen Therapy (HBOT) session.
Following your first treatment session, our Renue chauffeur will return you to your hotel.
Evening
Do you have any plans for the evening? Or maybe you would need a chauffeur?
Remember that relaxation can improve your health, too. Ask our Renue chauffeur for suggestions. They know the places to go in Puerto Vallarta.
Treatment Day & Second Hyperbaric Session
Day 2. Now you're a pro!
Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Medical Centre.
The medical team will welcome you and start your treatment for Systemic Lupus Erythematosus as soon as you arrive:
300 Million Stem Cells IV*
16 Billion Exosomes*
*The actual quantity of Stem Cells depends on the patient’s body weight and severity of the disease.
Then, after your treatment and second Hyperbaric Chamber session, the Renue chauffeur will return you to the hotel.
Evening
Puerto Vallarta is a beautiful place; we suggest you don't miss out and enjoy your stay. You know it: ask our Renue chauffeur for suggestions and have fun!
The third Hyperbaric session makes a difference.
Day 3. You're almost done.
Our Renue chauffeur will pick you up according to the schedule and take you to The Renue Centre.
Your scheduled treatment will start as soon as you arrive.
Then, after your treatment and second Hyperbaric Chamber session, the Renue chauffeur will return you to the hotel.
Evening
Your Renue Journey allows you to explore all that Puerto Vallarta has to offer.
Ask our Renue chauffeur for suggestions, and remember to enjoy yourself.
It's not over yet.
Day 4. Departure or extended stay?
Our Renue chauffeur will pick you up from the hotel. Then, they will take you to the airport or another treatment according to your schedule.
However, maybe you would like to extend your stay and your wellness holiday because Puerto Vallarta is stunning!
Talk to our Renue chauffeur. Our team will contact you to confirm all details: tours, restaurants, and other treatments you would like to have.
Are you going to miss us?
Don't forget our follow-up treatments. Talk to your Patient Advisor:
30, 60 & 90 days follow-up: SLE symptoms clinical evaluation, flare-up frequency, and lab test results.
Six months post-treatment: SLE symptoms clinical evaluation, flare-up frequency, lab test results, X-ray report, and review of the diagnostic criteria from the American College of Rheumatology.
Significance of Hyperbaric Chambers post-treatment:
Hyperbaric Chambers are oxygen-rich chambers.
At sea level, normal air carries 21% oxygen, but the patients enclosed in a Hyperbaric Chamber receive 100% oxygen. This quantity of oxygen stimulates only the red blood cells when taken routinely over the ground.
Significantly high amounts of oxygen are used in the chamber. On the other hand, oxygen dissolves in all physiological fluids, particularly plasma and fluids in the central nervous system. These high levels of oxygen consumed by the body will accelerate the levels of DNA, resulting in enhanced healing processes.
Benefits are:
Increased stem cell concentration
Enhance regeneration process
Relax the immune system to let it function in the body's favour
EXPECTED RESULTS
SCT to live a better life: Benefits and outcomes
The effectiveness of Stem Cell Treatment can improve all your symptoms, causing a considerable impact on your quality of life and daily activities.
As part of The Renue Difference, you will receive three Hyperbaric Chamber sessions that greatly improve SCT efficacy and stimulate the body cells to combat Systemic Lupus Erythematosus. These sessions comprise three days: one day before treatment, after treatment, and on the day of treatment.
According to results, clinical outcomes, and pre-and post-treatment observations, SCT has been shown to help
Reduce Lupus progression
Speed up tissue repair
Regrow and repair tissues after six months
After the SCT procedure, an MRI test depicts the further need for the treatment at a specific body site.
Talk to our Patient Advisor to know more about SCT at The Renue Medical Centre.
Expected results and prognosis:
Increased life expectancy
Improved life quality
Fewer levels of stress, fatigue, and health
FREQUENT QUESTIONS
What are the risks of Stem Cell Therapy for Lupus?
Stem Cell Therapy has the potential to cure degenerative disorders and injured tissue repair. Despite the therapeutic promise of Stem Cell Treatments, there are still hazards that have yet to be identified as:
Status of cell differentiation
Proliferation capacity of Stem Cells
Location and route of administration
Long-term survival of injected Stem Cells
In the event of irreparable tissue loss, the potential for simultaneous tissue regeneration
Management of Risks
The risks connected with Stem Cell Treatment are presently minimal and uncommon. When patients exhibit adverse effects, cautious care is usually recommended. Over-the-counter drugs can help reduce negative effects in cases of infections and inflammation. Pre-operative care and patient records are very important in controlling and reducing risk factors.
Stem Cell Therapy is a new and promising method of treating Systemic Lupus Erythematosus. It has the potential to be more effective than previous methods and also carries less risk. At present, Stem Cell Technology is still in the developmental stage, but rapid developments and advances indicate its potential uses in direct treatments of Systemic Lupus Erythematosus.
The benefits and effects of Stem Cell Therapy depend on several factors: the patient's health condition, underlying issues, lifestyle, and others.
To assess your expected results, we would like to know more about you.
A medical advisor will talk to you about your diagnosis and treatment options and collect information for the attending physician; they can answer all your initial questions:
Will the therapy work for my case?
What does the treatment involve? Is it painful?
Is it expensive? How much does it cost?
Start your Wellness Journey!
Click on the button below to book a consultation to answer your questions and discuss your medical history, your treatment journey, and your goals.